CD40

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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-ZP7034 Anti-CD40 (Bleselumab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Bleselumab Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7035 Anti-CD40 (Bleselumab) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human Bleselumab Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7036 Anti-CD40 (12E12.3F3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 12E12.3F3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7037 Anti-CD40 (12E12.3F3) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 12E12.3F3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7076 Anti-CD40 (BMS3h-1) h(CD28-CD3ζ) CAR, pCDCAR1 Human BMS3h-1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7077 Anti-CD40 (BMS3h-1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human BMS3h-1 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7078 Anti-CD40 (11B6.1C3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 11B6.1C3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7079 Anti-CD40 (11B6.1C3) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 11B6.1C3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7080 Anti-CD40 (20C4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4A3A8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7129 Anti-CD40 (F5-157) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human F5-157 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7130 Anti-CD40 (21.4.1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 21.4.1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7131 Anti-CD40 (21.4.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 21.4.1 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7132 Anti-CD40 (3.1.1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3.1.1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7133 Anti-CD40 (3.1.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 3.1.1 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7193 Anti-CD40 (647CT13.2.4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 647CT13.2.4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7194 Anti-CD40 (27G1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 27G1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7195 Anti-CD40 (27G1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 27G1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7196 Anti-CD40 (AG31) h(CD28-CD3ζ) CAR, pCDCAR1 Human AG31 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7197 Anti-CD40 (AG31) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human AG31 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7198 Anti-CD40 (5C3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5C3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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