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CD40

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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ6874 Anti-CD40 (21.4.1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 21.4.1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7354 Anti-CD40 (21.4.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 21.4.1 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7018 Anti-CD40 (S2C6) h(CD28-CD3ζ) CAR, pCDCAR1 Human S2C6 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7046 Anti-CD40 (BMS3h-106) h(CD28-CD3ζ) CAR, pCDCAR1 Human BMS3h-106 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7047 Anti-CD40 (BMS3h-106) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human BMS3h-106 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7048 Anti-CD40 (HuAb1) h(CD28-CD3ζ) CAR, pCDCAR1 Human HuAb1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7049 Anti-CD40 (HuAb1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human HuAb1 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7050 Anti-CD40 (PPAT-071-07) h(CD28-CD3ζ) CAR, pCDCAR1 Human PPAT-071-07 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7110 Anti-CD40 (2.22) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2.22 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7111 Anti-CD40 (2.22) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2.22 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7112 Anti-CD40 (38-4B7) h(CD28-CD3ζ) CAR, pCDCAR1 Human 38-4B7 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7113 Anti-CD40 (38-4B7) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 38-4B7 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7114 Anti-CD40 (7E1-G2b) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 7E1-G2b Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7115 Anti-CD40 (7E1-G2b) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 7E1-G2b Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7116 Anti-CD40 (AB009) h(CD28-CD3ζ) CAR, pCDCAR1 Human AB009 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7175 Anti-CD40 (3A4B7) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 3A4B7 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7176 Anti-CD40 (39530) h(CD28-CD3ζ) CAR, pCDCAR1 Human 39530 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7177 Anti-CD40 (39530) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 39530 Rat scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7178 Anti-CD40 (8G5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 8G5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7179 Anti-CD40 (8G5) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 8G5 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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