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The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-L349-2 | Anti-CSH1 scFv h(CD28) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-L349-G | Anti-CSH1 scFv h(FcεRIγ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-L349-Z | Anti-CSH1 scFv h(CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L349-2G | Anti-CSH1 scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L349-2Z | Anti-CSH1 scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L349-4G | Anti-CSH1 scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L349-4Z | Anti-CSH1 scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD4-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L349-8Z | Anti-CSH1 scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L349-BZ | Anti-CSH1 scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L349-CZ | Anti-CSH1 scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-b2c-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L349-2BZ | Anti-CSH1 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L349-2XZ | Anti-CSH1 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | 162.1 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | ||
| XS-1222-ZP481 | CSH1 (PRLR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 | Human | CSH1-CD28-CD6ζ | Lentiviral vector | T cell | ||||
| XS-1222-ZP1881 | CSH1 (PRLR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 | Human | CSH1-41BB-CD6ζ | Lentiviral vector | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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