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CSH1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.

Associated Disease
  • Multiple myeloma (MM)
  • Melanoma
  • CAR Vector Products
  • CAR Viral Particles
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  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-L349-2 Anti-CSH1 scFv h(CD28) CART, pCDCAR1 Human 162.1 Mouse scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L349-G Anti-CSH1 scFv h(FcεRIγ) CART, pCDCAR1 Human 162.1 Mouse scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L349-Z Anti-CSH1 scFv h(CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-2G Anti-CSH1 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-2Z Anti-CSH1 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-4G Anti-CSH1 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-4Z Anti-CSH1 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-8Z Anti-CSH1 scFv h(CD8-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-BZ Anti-CSH1 scFv h(41BB-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L349-CZ Anti-CSH1 scFv h(b2c-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L349-2BZ Anti-CSH1 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L349-2XZ Anti-CSH1 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human 162.1 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet

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