CSH1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.

Associated Disease
  • Multiple myeloma (MM)
  • Melanoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-L349-2 T cell First 162.1 7384bp Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L349-G T cell First 162.1 7384bp Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L349-Z T cell First 162.1 7384bp Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L349-2G T cell Second 162.1 7384bp Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L349-2Z T cell Second 162.1 7384bp Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L349-4G T cell Second 162.1 7384bp Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L349-4Z T cell Second 162.1 7384bp Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L349-8Z T cell Second 162.1 7384bp Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L349-BZ T cell Second 162.1 7384bp Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L349-CZ T cell Second 162.1 7384bp Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L349-2BZ T cell Third 162.1 7384bp Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L349-2XZ T cell Third 162.1 7384bp Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC157 162.1 Lentivirus First scFv (162.1)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC158 162.1 Lentivirus First scFv (162.1)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC159 162.1 Lentivirus First scFv (162.1)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC160 162.1 Lentivirus Second scFv (162.1)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC161 162.1 Lentivirus Second scFv (162.1)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC162 162.1 Lentivirus Second scFv (162.1)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC163 162.1 Lentivirus Second scFv (162.1)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC164 162.1 Lentivirus Second scFv (162.1)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC165 162.1 Lentivirus Second scFv (162.1)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC166 162.1 Lentivirus Second scFv (162.1)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC167 162.1 Lentivirus Third scFv (162.1)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC168 162.1 Lentivirus Third scFv (162.1)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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