All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
EBV is the causative agent of infectious mononucleosis and is associated with several human lymphoid and epithelial malignancies including Burkitt's lymphoma, nasopharyngeal carcinoma (NPC), T-cell lymphoma and Hodgkin's disease. EBV LMP-1, Epstein-Barr virus latent membrane protein 1,is an virus(EBV) protein that regulates its own expression and the expression of human genes. LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers. LMP1 can stimulate or inhibit signaling pathways, resulting in transformation of rodent fibroblast cell lines, blockade of differentiation in epithelial cells, upregulation of anti-apoptotic proteins, production of cytokines, upregulation of cell surface markers, upregulation of DNA methyltransferase activity, and downregulation of cell adhesion molecules and cyclin-dependent kinases.
CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
CAR-LC156 | Anti-EBV LMP1 h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | Human | scFv-CD28-41BB-CD3ζ | Retroviral | T cell | |||
XS-1022-ZP225 | Anti-EBV LMP1 (A4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | A4 | Human | scFv-41BB-CD41ζ | Lentiviral vector | T cell | ||
XS-1022-ZP226 | Anti-EBV LMP1 (A4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | A4 | Human | scFv-CD28-CD41ζ | Lentiviral vector | T cell | ||
XS-1022-ZP227 | Anti-EBV LMP1 (E2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | E2 | Human | scFv-41BB-CD40ζ | Lentiviral vector | T cell | ||
XS-1022-ZP228 | Anti-EBV LMP1 (E2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | E2 | Human | scFv-CD28-CD40ζ | Lentiviral vector | T cell | ||
XS-1022-ZP233 | Anti-EBV LMP1 (F5) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | F5 | Human | scFv-41BB-CD41ζ | Lentiviral vector | T cell | ||
XS-1022-ZP234 | Anti-EBV LMP1 (F5) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | F5 | Human | scFv-CD28-CD41ζ | Lentiviral vector | T cell | ||
XS-1022-ZP235 | Anti-EBV LMP1 (36) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 36 | Human | scFv-41BB-CD42ζ | Lentiviral vector | T cell | ||
XS-1022-ZP236 | Anti-EBV LMP1 (36) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 36 | Human | scFv-CD28-CD42ζ | Lentiviral vector | T cell |
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