EGP-2

The EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body. The EpCAM protein is found spanning the membrane that surrounds epithelial cells, where it helps cells stick to one another (cell adhesion). In addition, the protein in the cell membrane can be cut at a specific location, releasing a piece called the intracellular domain (EpICD), which helps relay signals from outside the cell to the nucleus of the cell. EpICD travels to the nucleus and associates with other proteins, forming a group (complex) that regulates the activity of several genes that are involved in cell growth and division (proliferation), maturation (differentiation), and movement (migration), all of which are important processes for the proper development of cells and tissues.

Associated Disease
  • EGP-2+ colon cancer
  • Colorectal cancer

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-M316-2 T cell First GA733.2 8kb Lentiviral scFv-CD28 Human and Rat Inquiry
CAR-T-1-M316-G T cell First GA733.2 8kb Lentiviral scFv-FcεRIγ Human and Rat Inquiry
CAR-T-1-M316-Z T cell First GA733.2 8kb Lentiviral scFv-CD3ζ Human and Rat Inquiry
CAR-T-2-M316-2G T cell Second GA733.2 8kb Lentiviral scFv-CD28-FcεRIγ Human and Rat Inquiry
CAR-T-2-M316-2Z T cell Second GA733.2 8kb Lentiviral scFv-CD28-CD3ζ Human and Rat Inquiry
CAR-T-2-M316-4G T cell Second GA733.2 8kb Lentiviral scFv-CD4-FcεRIγ Human and Rat Inquiry
CAR-T-2-M316-4Z T cell Second GA733.2 8kb Lentiviral scFv-CD4-CD3ζ Human and Rat Inquiry
CAR-T-2-M316-8Z T cell Second GA733.2 8kb Lentiviral scFv-CD8-CD3ζ Human and Rat Inquiry
CAR-T-2-M316-BZ T cell Second GA733.2 8kb Lentiviral scFv-41BB-CD3ζ Human and Rat Inquiry
CAR-T-2-M316-CZ T cell Second GA733.2 8kb Lentiviral scFv-b2c-CD3ζ Human and Rat Inquiry
CAR-T-3-M316-2BZ T cell Third GA733.2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Human and Rat Inquiry
CAR-T-3-M316-2XZ T cell Third GA733.2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Human and Rat Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC209 GA733.2 Lentivirus First scFv (GA733.2)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC210 GA733.2 Lentivirus First scFv (GA733.2)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC211 GA733.2 Lentivirus First scFv (GA733.2)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC212 GA733.2 Lentivirus Second scFv (GA733.2)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC213 GA733.2 Lentivirus Second scFv (GA733.2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC214 GA733.2 Lentivirus Second scFv (GA733.2)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC215 GA733.2 Lentivirus Second scFv (GA733.2)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC216 GA733.2 Lentivirus Second scFv (GA733.2)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC217 GA733.2 Lentivirus Second scFv (GA733.2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC218 GA733.2 Lentivirus Second scFv (GA733.2)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC219 GA733.2 Lentivirus Third scFv (GA733.2)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC220 GA733.2 Lentivirus Third scFv (GA733.2)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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