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Nonhuman primates can be used to study host immune responses to Mycobacterium tuberculosis Mauritian cynomolgus macaques (MCMs) are a unique group of animals that have limited major histocompatibility complex (MHC) genetic diversity, such that MHC-identical animals can be infected with M. tuberculosis Two MCMs homozygous for the relatively common M1 MHC haplotype were bronchoscopically infected with 41 CFU of the M. tuberculosis Erdman strain. Four other MCMs, which had at least one copy of the M1 MHC haplotype, were infected with a lower dose of 3 CFU M. tuberculosis All animals mounted similar T-cell responses to CFP-10 and ESAT-6. Two epitopes in CFP-10 were characterized, and the MHC class II alleles restricting them were determined. A third epitope in CFP-10 was identified but exhibited promiscuous restriction. The CFP-10 and ESAT-6 antigenic regions targeted by T cells in MCMs were comparable to those seen in cases of human M. tuberculosis infection.
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CAT Product Name Target Species TCR Clone Host Species Epitope Allele Vector Type Inquiry & Datasheet
TCR-YC0379 Human anti-esxH T cell receptor (TCR098), pCDTCR1 Mycobacterium tuberculosis TCR098 Human MSQIMYNYPAMLGHA HLA-DRB3*03:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YC0380 Human anti-esxH T cell receptor (TCR099), pCDTCR1 Mycobacterium tuberculosis TCR099 Human MSQIMYNYPAMRAHA HLA-DRB3*03:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YC0381 Mouse anti-esxH T cell receptor (TCR3), pCDTCR1 Mycobacterium tuberculosis TCR3 Mouse IMYNYPAM H2-Kᵇ Lentiviral vector   Add to Cart   Datasheet
TCR-ZP206 Human anti-esxH T cell receptor (), pCDTCR1 Mycobacterium tuberculosis Human AAVVRFQEAANKQK HLA-DR Lentiviral vector   Add to Cart   Datasheet
TCR-ZP207 Mouse anti-esxH T cell receptor (P25), pCDTCR1 Mycobacterium tuberculosis P25 Mouse IMYNYPAM H-2Kb Lentiviral vector   Add to Cart   Datasheet
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