FcRL5

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307 (cluster of differentiation 307). This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. FcRL5 was expressed at elevated levels on the surface of plasma cells from the bone marrow of patients diagnosed with multiple myeloma. This prevalence in multiple myeloma and narrow pattern of normal expression indicate that FcRL5 could be a target for antibody-based therapies for multiple myeloma.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC205 T cell Second F56 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC206 T cell Second F119 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC207 T cell Second ET200-31 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC208 T cell Second ET200-39 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC209 T cell Second ET200-69 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC210 T cell Second ET200-104 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC211 T cell Second ET200-105 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC212 T cell Second ET200-109 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC213 T cell Second ET200-117 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC681 F56 Lentivirus Second scFv (F56)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC682 F119 Lentivirus Second scFv (F119)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC683 ET200-31 Lentivirus Second scFv (ET200-31)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC684 ET200-39 Lentivirus Second scFv (ET200-39)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC685 ET200-69 Lentivirus Second scFv (ET200-69)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC686 ET200-104 Lentivirus Second scFv (ET200-104)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC687 ET200-105 Lentivirus Second scFv (ET200-105)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC688 ET200-109 Lentivirus Second scFv (ET200-109)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC689 ET200-117 Lentivirus Second scFv (ET200-117)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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