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gp41

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The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells, apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.Env is a viral gene that encodes the protein forming the viral envelope. The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane.Env is a viral gene that encodes the protein forming the viral envelope. The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane.

Associated Disease
  • HIV-1 infection
  • CAR Vector Products

  • TCR Vector Products

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-T-2-LX364 Anti-HIV (8062) h(CD28-CD3ζ) CAR, pCDCAR1 Human 8062 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX370 Anti-HIV (HK20) h(CD28-CD3ζ) CAR, pCDCAR1 Human HK20 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX397 Anti-HIV (VRC42.04) h(CD28-CD3ζ) CAR, pCDCAR1 Human VRC42.04 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX405 Anti-HIV (13H11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 13H11 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX429 Anti-HIV (8062) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 8062 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX435 Anti-HIV (HK20) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human HK20 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX462 Anti-HIV (VRC42.04) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human VRC42.04 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX470 Anti-HIV (13H11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 13H11 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX490 Anti-HIV (Z13e) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human Z13e Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX491 Anti-HIV (17b) (CD4-scFv-h(CD28-CD3ζ)) bNAb CAR, pCDCAR1 Human 17b Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX560 Anti-HIV (F240) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human F240 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX589 Anti-HIV (8066) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human 8066 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX609 Anti-HIV (DH570) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human DH570 Macaque CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX670 Anti-HIV (8062) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human 8062 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX676 Anti-HIV (HK20) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human HK20 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX703 Anti-HIV (VRC42.04) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human VRC42.04 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX711 Anti-HIV (13H11) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 Human 13H11 Human CD4-scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX731 Anti-HIV (Z13e) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 Human Z13e Human CD4-scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX732 Anti-HIV (17b) (CD4-scFv-h(4-1BB-CD3ζ)) bNAb CAR, pCDCAR1 Human 17b Human CD4-scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-LX801 Anti-HIV (F240) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 Human F240 Human CD4-scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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