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HLA-A

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HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY6753 Anti-HLA-A (CBFYH-2885) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Monkey, Cattle CBFYH-2885 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6754 Anti-HLA-A (CBFYH-2886) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Cattle, Primate CBFYH-2886 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6755 Anti-HLA-A (CBFYH-2887) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-2887 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6756 Anti-HLA-A (CBFYH-2888) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-2888 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6762 Anti-HLA-A (CBFYH-1246) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1246 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6763 Anti-HLA-A (CBFYH-1245) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1245 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6767 Anti-HLA-A (CBFYH-1264) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1264 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6775 Anti-HLA-A (CBFYH-1266) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1266 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6779 Anti-HLA-A (CBFYH-1268) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1268 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6815 Anti-HLA-A (BB7-2) h(41BB-CD3ζ) CAR, pCDCAR1 Human BB7-2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6816 Anti-HLA-A (CATA-1) h(41BB-CD3ζ) CAR, pCDCAR1 Human CATA-1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6817 Anti-HLA-A (HCA2) h(41BB-CD3ζ) CAR, pCDCAR1 Human HCA2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6818 Anti-HLA-A (CBFYH-1247) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat, Pig CBFYH-1247 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6819 Anti-HLA-A (CBFYH-1249) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1249 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6820 Anti-HLA-A (CBFYH-1250) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1250 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6821 Anti-HLA-A (CBFYH-1251) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1251 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6822 Anti-HLA-A (CBFYH-1252) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1252 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY6823 Anti-HLA-A (CBFYH-1253) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-1253 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7541 Anti-HLA-A (CBFYH-1262) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-1262 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7560 Anti-HLA-A (CBFYH-1246) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-1246 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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