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INPP5D

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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ1417 Anti-INPP5D (SHIP-01) h(41BB-CD3ζ) CAR, pCDCAR1 Human SHIP-01 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1418 Anti-INPP5D (SHIP-02) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse SHIP-02 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1419 Anti-INPP5D (CBXS-5990) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-5990 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1420 Anti-INPP5D (CBXS-5997) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-5997 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1421 Anti-INPP5D (CBXS-5555) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-5555 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1422 Anti-INPP5D (CBXS-1206) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-1206 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1423 Anti-INPP5D (CBXS-1508) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-1508 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1424 Anti-INPP5D (CBXS-1742) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXS-1742 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1425 Anti-INPP5D (CBXS-2125) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-2125 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1426 Anti-INPP5D (CBXS-3567) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXS-3567 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1427 Anti-INPP5D (CBXS-6165) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-6165 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4841 Anti-INPP5D (SHIP-01) h(CD28-CD3ζ) CAR, pCDCAR1 Human SHIP-01 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4842 Anti-INPP5D (SHIP-02) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse SHIP-02 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4843 Anti-INPP5D (CBXS-5990) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-5990 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4844 Anti-INPP5D (CBXS-5997) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-5997 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4845 Anti-INPP5D (CBXS-5555) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-5555 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4846 Anti-INPP5D (CBXS-1206) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-1206 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4847 Anti-INPP5D (CBXS-1508) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-1508 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4848 Anti-INPP5D (CBXS-1742) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXS-1742 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4849 Anti-INPP5D (CBXS-2125) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-2125 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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