MP

Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.

Associated Disease
  • Influenza

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C164Z MP IAV Human ~8kb Lentiviral GILGFVFTL Non-modified HLA-A2 Inquiry
TCR-C165Z MP IAV JM22 Human ~8kb Lentiviral GILGFVFTL Non-modified HLA-A2 Inquiry
TCR-C166Z MP IAV PF8 Human ~8kb Lentiviral GILGFVFTL Non-modified HLA-A2 Inquiry
TCR-C167Z MP IAV PF6 Human ~8kb Lentiviral GILGFVFTL Non-modified HLA-A2 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C307 IAV JM22 Human Lentivirus GILGFVFTL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C308 IAV PF8 Human Lentivirus GILGFVFTL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C309 IAV PF6 Human Lentivirus GILGFVFTL Non-modified TCR > 10⁷ IFU/ml Inquiry
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