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Anti-MP T cell receptor (JM22), pCDTCR1 (TCR-C165Z)

The vector of anti-MP T cell receptor (TCR) is constructed for the engineering of T cell to target IAV MP. The T cells are genetically modified through transduction with a lentiviral vector expressing MP-specific T cell receptor. And the vector product was designed for the treatment of Influenza.

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Details

  • Target
  • MP
  • Target Species
  • IAV
  • Epitope
  • GILGFVFTL
  • Format
  • Non-modified
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Influenza
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • JM22
  • Antibody Host
  • Human

Target

  • Official Symbol
  • MP
  • Introduction
  • Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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