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NS5A

HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV has four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS5A is a hydrophilic phosphoprotein which plays an important role in viral replication, modulation of cell signaling pathways and the interferon response. It is known to bind to endoplasmic reticulum anchored human VAP proteins.

Associated Disease
  • HCV infection
  • TCR Vector Products
  • TCR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Epitope HLA Vector Type  
TCR-C185Z Mouse anti-NS5A T cell receptor (19), pCDTCR1 HCV 19 Mouse VLTDFKTWL HLA-A2 Lentiviral   Inquiry
  Datasheet
TCR-C186Z Mouse anti-NS5A T cell receptor (69), pCDTCR1 HCV 69 Mouse VLTDFKTWL HLA-A2 Lentiviral   Inquiry
  Datasheet

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