NY-BR-1

NY-BR-1 is a differentiation antigen of the mammary tissue, since it has been detected solely in the epithelial cells of mammary ducts and lobules, whereas NY-BR-1 expression has not been found in any other tissue. Thus, NY-BR-1 appears to be a breast-specific protein. In preliminary studies, NY-BR-1 mRNA was detected predominantly in breast cancers, and bioinformatic analysis annotated NY-BR-1 as a potential transcription factor. NY-BR-1 protein was shown to be expressed in normal breast epithelia and in the majority of primary breast cancers. NY-BR-1 may represent a potential target antigen for antibody-based therapy in breast cancer. Its frequent expression in breast cancer patients, its cell surface localization and accessibility to the monoclonal antibody mark NY-BR-1 as an attractive target.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC218 T cell Second ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC219 T cell Second ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC220 T cell Third ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC693 Lentivirus Second scFv-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC694 Lentivirus Second scFv-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC695 Lentivirus Second scFv-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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