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NY-BR-1 is a differentiation antigen of the mammary tissue, since it has been detected solely in the epithelial cells of mammary ducts and lobules, whereas NY-BR-1 expression has not been found in any other tissue. Thus, NY-BR-1 appears to be a breast-specific protein. In preliminary studies, NY-BR-1 mRNA was detected predominantly in breast cancers, and bioinformatic analysis annotated NY-BR-1 as a potential transcription factor. NY-BR-1 protein was shown to be expressed in normal breast epithelia and in the majority of primary breast cancers. NY-BR-1 may represent a potential target antigen for antibody-based therapy in breast cancer. Its frequent expression in breast cancer patients, its cell surface localization and accessibility to the monoclonal antibody mark NY-BR-1 as an attractive target.
CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
CAR-LC218 | Anti-NY-BR-1 h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |||
CAR-LC219 | Anti-NY-BR-1 h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Mouse | scFv-41BB-CD3ζ | Retroviral | T cell | |||
CAR-LC220 | Anti-NY-BR-1 h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | Mouse | scFv-CD28-41BB-CD3ζ | Retroviral | T cell |
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