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pM45

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Murine CMV (MCMV) is a natural herpesvirus infection of mice and thus provides a good model to study the effects of immune evasion on the host immune response. This paper investigates the effect of an immune evasion gene that profoundly inhibits presentation of a viral epitope on the immunodominance of that epitope. MCMV encodes three genes, m4, m6, and m152, which interfere with Ag presentation to CD8 T cells. The m4/gp34 protein binds to MHC class I molecules in the endoplasmic reticulum (ER) and on the cell surface. The m6/gp48 protein redirects class I to the lysosome for degradation. Finally, m152 retains class I in the ER cis-Golgi intermediate compartment.
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CAT Product Name Target Species TCR Clone Host Species Epitope Allele Vector Type Inquiry & Datasheet
TCR-YC1001 Mouse anti-pM45 T cell receptor (491), pCDTCR1 MuHV1 491 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1002 Mouse anti-pM45 T cell receptor (522), pCDTCR1 MuHV1 522 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1003 Mouse anti-pM45 T cell receptor (611), pCDTCR1 MuHV1 611 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1004 Mouse anti-pM45 T cell receptor (711), pCDTCR1 MuHV1 711 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1005 Mouse anti-pM45 T cell receptor (809), pCDTCR1 MuHV1 809 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1006 Mouse anti-pM45 T cell receptor (914), pCDTCR1 MuHV1 914 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1007 Mouse anti-pM45 T cell receptor (1064), pCDTCR1 MuHV1 1064 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1008 Mouse anti-pM45 T cell receptor (1087), pCDTCR1 MuHV1 1087 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1009 Mouse anti-pM45 T cell receptor (1114), pCDTCR1 MuHV1 1114 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1010 Mouse anti-pM45 T cell receptor (1226), pCDTCR1 MuHV1 1226 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1011 Mouse anti-pM45 T cell receptor (1331), pCDTCR1 MuHV1 1331 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1012 Mouse anti-pM45 T cell receptor (1411), pCDTCR1 MuHV1 1411 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1013 Mouse anti-pM45 T cell receptor (1531), pCDTCR1 MuHV1 1531 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1014 Mouse anti-pM45 T cell receptor (1606), pCDTCR1 MuHV1 1606 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1015 Mouse anti-pM45 T cell receptor (1710), pCDTCR1 MuHV1 1710 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1016 Mouse anti-pM45 T cell receptor (1818), pCDTCR1 MuHV1 1818 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1017 Mouse anti-pM45 T cell receptor (1903), pCDTCR1 MuHV1 1903 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1018 Mouse anti-pM45 T cell receptor (2704), pCDTCR1 MuHV1 2704 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1019 Mouse anti-pM45 T cell receptor (2806), pCDTCR1 MuHV1 2806 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
TCR-YC1020 Mouse anti-pM45 T cell receptor (2944), pCDTCR1 MuHV1 2944 Mouse HGIRNASFI H2-Db Lentiviral vector   Add to Cart   Datasheet
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