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Tumor Endothelial Marker 8 (TEM8),usually known as anthrax toxin receptor 1, is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-L343-2 | Anti-TEM8 scFv h(CD28) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-L343-G | Anti-TEM8 scFv h(FcεRIγ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-L343-Z | Anti-TEM8 scFv h(CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L343-2G | Anti-TEM8 scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L343-2Z | Anti-TEM8 scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L343-4G | Anti-TEM8 scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L343-4Z | Anti-TEM8 scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD4-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L343-8Z | Anti-TEM8 scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L343-BZ | Anti-TEM8 scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L343-CZ | Anti-TEM8 scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-b2c-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L343-2BZ | Anti-TEM8 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L343-2XZ | Anti-TEM8 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | SB5 | Goat | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | ||
| CAR-YF094 | Anti-TEM8 (CBL-YF030) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF030 | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF095 | Anti-TEM8 (CBL-YF030) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF030 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6467 | Anti-TEM8 (L2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | L2 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6468 | Anti-TEM8 (L2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | L2 | Human | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6469 | Anti-TEM8 (L4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | L4 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6470 | Anti-TEM8 (L4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | L4 | Human | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6471 | Anti-TEM8 (L1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | L1 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP6472 | Anti-TEM8 (L1) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | L1 | Human | scFv-41BB-CD3ζ | Lentiviral vector | T cell |
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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