TEM8

Tumor Endothelial Marker 8 (TEM8),usually known as anthrax toxin receptor 1, is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Associated Disease
  • Glioma
  • Breast cancer

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-L343-2 T cell First SB5 8kb Lentiviral scFv-CD28 Goat Inquiry
CAR-T-1-L343-G T cell First SB5 8kb Lentiviral scFv-FcεRIγ Goat Inquiry
CAR-T-1-L343-Z T cell First SB5 8kb Lentiviral scFv-CD3ζ Goat Inquiry
CAR-T-2-L343-2G T cell Second SB5 8kb Lentiviral scFv-CD28-FcεRIγ Goat Inquiry
CAR-T-2-L343-2Z T cell Second SB5 8kb Lentiviral scFv-CD28-CD3ζ Goat Inquiry
CAR-T-2-L343-4G T cell Second SB5 8kb Lentiviral scFv-CD4-FcεRIγ Goat Inquiry
CAR-T-2-L343-4Z T cell Second SB5 8kb Lentiviral scFv-CD4-CD3ζ Goat Inquiry
CAR-T-2-L343-8Z T cell Second SB5 8kb Lentiviral scFv-CD8-CD3ζ Goat Inquiry
CAR-T-2-L343-BZ T cell Second SB5 8kb Lentiviral scFv-41BB-CD3ζ Goat Inquiry
CAR-T-2-L343-CZ T cell Second SB5 8kb Lentiviral scFv-b2c-CD3ζ Goat Inquiry
CAR-T-3-L343-2BZ T cell Third SB5 8kb Lentiviral scFv-CD28-41BB-CD3ζ Goat Inquiry
CAR-T-3-L343-2XZ T cell Third SB5 8kb Lentiviral scFv-CD28-OX40-CD3ζ Goat Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC473 SB5 Lentivirus First scFv (SB5)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC474 SB5 Lentivirus First scFv (SB5)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC475 SB5 Lentivirus First scFv (SB5)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC476 SB5 Lentivirus Second scFv (SB5)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC477 SB5 Lentivirus Second scFv (SB5)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC478 SB5 Lentivirus Second scFv (SB5)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC479 SB5 Lentivirus Second scFv (SB5)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC480 SB5 Lentivirus Second scFv (SB5)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC481 SB5 Lentivirus Second scFv (SB5)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC482 SB5 Lentivirus Second scFv (SB5)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC483 SB5 Lentivirus Third scFv (SB5)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC484 SB5 Lentivirus Third scFv (SB5)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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