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TEM8

Tumor Endothelial Marker 8 (TEM8),usually known as anthrax toxin receptor 1, is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Associated Disease
  • Glioma
  • Breast cancer
  • CAR Vector Products
  • CAR Viral Particles
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-3-L343-2BZ Anti-TEM8 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L343-2XZ Anti-TEM8 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L343-2 Anti-TEM8 scFv h(CD28) CART, pCDCAR1 Human SB5 Goat scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L343-G Anti-TEM8 scFv h(FcεRIγ) CART, pCDCAR1 Human SB5 Goat scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L343-Z Anti-TEM8 scFv h(CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-2G Anti-TEM8 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human SB5 Goat scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-2Z Anti-TEM8 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-4G Anti-TEM8 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human SB5 Goat scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-4Z Anti-TEM8 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-8Z Anti-TEM8 scFv h(CD8-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L343-BZ Anti-TEM8 scFv h(41BB-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-YF094 Anti-TEM8 (CBL-YF030) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF030 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF095 Anti-TEM8 (CBL-YF030) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF030 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-T-2-L343-CZ Anti-TEM8 scFv h(b2c-CD3ζ) CART, pCDCAR1 Human SB5 Goat scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-ZP6467 Anti-TEM8 (L2) h(CD28-CD3ζ) CAR, pCDCAR1 Human L2 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6468 Anti-TEM8 (L2) h(41BB-CD3ζ) CAR, pCDCAR1 Human L2 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6469 Anti-TEM8 (L4) h(CD28-CD3ζ) CAR, pCDCAR1 Human L4 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6470 Anti-TEM8 (L4) h(41BB-CD3ζ) CAR, pCDCAR1 Human L4 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6471 Anti-TEM8 (L1) h(CD28-CD3ζ) CAR, pCDCAR1 Human L1 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6472 Anti-TEM8 (L1) h(41BB-CD3ζ) CAR, pCDCAR1 Human L1 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6473 Anti-TEM8 (L3) h(CD28-CD3ζ) CAR, pCDCAR1 Human L3 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6474 Anti-TEM8 (L3) h(41BB-CD3ζ) CAR, pCDCAR1 Human L3 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6475 Anti-TEM8 (1D2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1D2 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6476 Anti-TEM8 (1D2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1D2 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6477 Anti-TEM8 (200C1339) h(CD28-CD3ζ) CAR, pCDCAR1 Human 200C1339 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6478 Anti-TEM8 (200C1339) h(41BB-CD3ζ) CAR, pCDCAR1 Human 200C1339 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6479 Anti-TEM8 (SB20) h(CD28-CD3ζ) CAR, pCDCAR1 Human SB20 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6480 Anti-TEM8 (SB20) h(41BB-CD3ζ) CAR, pCDCAR1 Human SB20 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6481 Anti-TEM8 (7H149) h(CD28-CD3ζ) CAR, pCDCAR1 Human 7H149 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6482 Anti-TEM8 (7H149) h(41BB-CD3ζ) CAR, pCDCAR1 Human 7H149 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6483 Anti-TEM8 (300D2440) h(CD28-CD3ζ) CAR, pCDCAR1 Human 300D2440 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6484 Anti-TEM8 (300D2440) h(41BB-CD3ζ) CAR, pCDCAR1 Human 300D2440 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6485 Anti-TEM8 (SB2) h(CD28-CD3ζ) CAR, pCDCAR1 Human SB2 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6486 Anti-TEM8 (SB2) h(41BB-CD3ζ) CAR, pCDCAR1 Human SB2 Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6487 Anti-TEM8 (SB4) h(CD28-CD3ζ) CAR, pCDCAR1 Human SB4 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6488 Anti-TEM8 (SB4) h(41BB-CD3ζ) CAR, pCDCAR1 Human SB4 Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6489 Anti-TEM8 (SB6) h(CD28-CD3ζ) CAR, pCDCAR1 Human SB6 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6490 Anti-TEM8 (SB6) h(41BB-CD3ζ) CAR, pCDCAR1 Human SB6 Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6491 Anti-TEM8 (SB12) h(CD28-CD3ζ) CAR, pCDCAR1 Human SB12 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP6492 Anti-TEM8 (SB12) h(41BB-CD3ζ) CAR, pCDCAR1 Human SB12 Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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