Closed

pCDCAR1 TEM8 h(FcεRIγ), T (CAR-T-1-L343-G)

The vector of anti-TEM8 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TEM8. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TEM8 antibody linked to FcεRIγ signaling domains. And the vector product was designed for cell therapy that targets tumor vasculature, including the tumor vascular bed, for example, glioma and breast cancer.

Details

  • Target
  • TEM8
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Glioma; breast cancer
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
  • Antibody Clone
  • SB5
  • Antibody Host
  • Goat

Target

  • Gene Name
  • anthrax toxin receptor 1
  • Official Symbol
  • TEM8
  • Synonyms
  • ATR; GAPO; TEM8; Anthrax toxin receptor 1; ANTR1_HUMAN; ANTXR 1; TEM 8; ATR; FLJ10601; FLJ11298; FLJ21776; Tumor Endothelial Marker 8; Tumor endothelial marker 8 precursor; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; SB5

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry
Products

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:

Online Inquiry

For any technical issues or products/services related questions, please leave your contacts as below, and our team will contact you at earliest convenience to let you know how we can be involved in your projects.

  • Verification code

Key Updates

Receive the latest news and insights to your inbox.