TRBC1

T-cell receptor beta constant 1 (TRBC1) is a protein that in humans is encoded by the TRBC1 gene. The α/β T-cell receptor (TCR) is a pan T-cell antigen, expressed on>90% of T-cell lymphomas and all normal T-cells. An overlooked feature of the TCR is that the β-constant region comprises 2 functionally identical genes: TRBC1 and TRBC2. Each T-cell expresses only one of these. Hence, normal T-cells will be a mixture of individual cells expressing either TRBC1 or 2, while a clonal T-cell cancer will express TRBC1 or 2 in its entirety.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC094 T cell Second Jovi-1 ~8kb Retroviral scFv-(CD8stk)-CD28-CD3ζ Mouse Inquiry
CAR-LC095 T cell Second Jovi-1 ~8kb Retroviral scFv-(CH2CH3pvaa)-CD28-CD3ζ Mouse Inquiry
CAR-LC096 T cell Second Jovi-1 ~8kb Retroviral scFv-(IgG1)-CD28-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC582 Jovi-1 Lentivirus Second scFv (Jovi-1)- (CD8stk)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC583 Jovi-1 Lentivirus Second scFv (Jovi-1)- (CH2CH3pvaa)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC584 Jovi-1 Lentivirus Second scFv (Jovi-1)- (IgG1)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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