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UBE3A

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This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY0643 Anti-UBE3A (CBFYE-0010) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYE-0010 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY0644 Anti-UBE3A (CBFYE-1682) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYE-1682 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY0645 Anti-UBE3A (CBFYE-1683) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYE-1683 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY3896 Anti-UBE3A (CBFYE-0010) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYE-0010 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY3897 Anti-UBE3A (CBFYE-1682) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYE-1682 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY3898 Anti-UBE3A (CBFYE-1683) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYE-1683 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY033 Anti-UBE3A (1A10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1A10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY034 Anti-UBE3A (1A2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1A2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY1673 Anti-UBE3A(1A10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1A10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY1674 Anti-UBE3A(1A2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1A2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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