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UL83

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

pp65 is the most abundant tegument protein and the major constituent of extracellular virus particles. However, pp65 is not essential for the production of new infectious virus particles as evidenced in strains that lack the pp65 gene which can still replicate in culture. pp65 is the major tegument protein responsible for modulating/evading the host cell immune response during HCMV infections. pp65 is implicated in counteracting both innate and adaptive immune responses during HCMV infections. pp65's role in immune evasion is largely attributable to its targeting of both humoral and cellular immunity as well as serving as the dominant target antigen of cytotoxic T lymphocytes. It has been demonstrated that pp65 not only prevents immediate-early proteins from being recognized by components of the immune system, but it also inhibits the synthesis of the various components involved in the host cell's immune response. One of the ways in which pp65 counteracts adaptive immunity is through its enzymatic kinase activity. It was shown that pp65 mediates the phosphorylation of viral immediate-early proteins, which blocks their presentation to the major histocompatibility complex class I molecules. The kinase activity of pp65 has also been implicated in causing the degradation of the alpha chain in the major histocompatibility class II cell surface receptor, HLA-DR, via an accumulation of HLA class II molecules in the lysosome. Furthermore, several studies have presented evidence that pp65 is involved in mediating a decrease in the expression of major histocompatibility complex class II molecules. This is significant in that major histocompatibility complex class I and II molecules are responsible for lymphocyte recognition and antigen presentation with class I molecules presenting to cytotoxic T lymphocytes CD8+ and class II molecules to helper T lymphocytes CD4+.

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CAT Product Name Target Species TCR Clone Host Species Epitope Allele Vector Type Inquiry & Datasheet
TCR-YC1303 Human anti-UL83 T cell receptor (10), pCDTCR1 HCMV 10 Human CPSQEPMSIYVY HLA-B*35:08 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1304 Human anti-UL83 T cell receptor (12), pCDTCR1 HCMV 12 Human EDVPSGKLFMHVTLG HLA class II Lentiviral vector   Add to Cart   Datasheet
TCR-YC1305 Human anti-UL83 T cell receptor (13), pCDTCR1 HCMV 13 Human ARNLVPMVATVQGQN HLA class II Lentiviral vector   Add to Cart   Datasheet
TCR-YC1306 Human anti-UL83 T cell receptor (A18), pCDTCR1 HCMV A18 Human IDLLLQRGPQYSEHPTFTSQYRI HLA-A*01:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1307 Human anti-UL83 T cell receptor (B20), pCDTCR1 HCMV B20 Human PPWQAGILARNLVPMVATVQGQN HLA-A*02:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1308 Human anti-UL83 T cell receptor (B3), pCDTCR1 HCMV B3 Human IDLLLQRGPQYSEHPTFTSQYRI HLA-A*01:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1309 Human anti-UL83 T cell receptor (k 1), pCDTCR1 HCMV k 1 Human CPSQEPMSIYVY HLA-B*35:08 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1310 Human anti-UL83 T cell receptor (k 2), pCDTCR1 HCMV k 2 Human CPSQEPMSIYVY HLA-B*35:08 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1311 Human anti-UL83 T cell receptor (r2β6), pCDTCR1 HCMV r2β6 Human CPSQEPMSIYVY HLA-B*35:08 Lentiviral vector   Add to Cart   Datasheet
TCR-YC1312 Human anti-UL83 T cell receptor (r6β), pCDTCR1 HCMV r6β Human CPSQEPMSIYVY HLA-B*35:08 Lentiviral vector   Add to Cart   Datasheet
TCR-YF322 Human anti-UL83 T cell receptor (BV16), pCDTCR1 Virus BV16 Human NLVPMVATV HLA-A2 Lentiviral vector   Add to Cart   Datasheet
TCR-YF323 Human anti-UL83 T cell receptor (BV8), pCDTCR1 Virus BV8 Human NLVPMVATV HLA-A2 Lentiviral vector   Add to Cart   Datasheet
TCR-YF324 Human anti-UL83 T cell receptor (C40), pCDTCR1 Virus C40 Human NLVPMVATV HLA-A*02:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YF325 Human anti-UL83 T cell receptor (D12), pCDTCR1 Virus D12 Human NLVPMVATV HLA-A2 Lentiviral vector   Add to Cart   Datasheet
TCR-YF326 Human anti-UL83 T cell receptor (KEL-12), pCDTCR1 Virus KEL-12 Human NLVPMVATV HLA-A*0201 Lentiviral vector   Add to Cart   Datasheet
TCR-YF329 Human anti-UL83 T cell receptor (CD40-29), pCDTCR1 CMV CD40-29 Human TPRVTGGGAM HLA-B*0702 Lentiviral vector   Add to Cart   Datasheet
TCR-YF331 Human anti-UL83 T cell receptor (AM41), pCDTCR1 CMV AM41 Human TPRVTGGGAM HLA-B*0702 Lentiviral vector   Add to Cart   Datasheet
TCR-YF332 Human anti-UL83 T cell receptor (UA1), pCDTCR1 Virus UA1 Human NLVPMVATV HLA-A*02:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YF333 Human anti-UL83 T cell receptor (UB9), pCDTCR1 Virus UB9 Human NLVPMVATV HLA-A*02:01 Lentiviral vector   Add to Cart   Datasheet
TCR-YF334 Human anti-UL83 T cell receptor (VA8), pCDTCR1 Virus VA8 Human NLVPMVATV HLA-A*02:01 Lentiviral vector   Add to Cart   Datasheet
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