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VEGFA

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This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY1643 Anti-VEGFA (XHM558) h(41BB-CD3ζ) CAR, pCDCAR1 Human XHM558 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY1644 Anti-VEGFA (XHM559) h(41BB-CD3ζ) CAR, pCDCAR1 Human XHM559 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY1645 Anti-VEGFA (XHM560) h(41BB-CD3ζ) CAR, pCDCAR1 Human XHM560 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2599 Anti-VEGFA (XHM561) h(41BB-CD3ζ) CAR, pCDCAR1 Human XHM561 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4896 Anti-VEGFA (XHM558) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM558 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4897 Anti-VEGFA (XHM559) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM559 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4898 Anti-VEGFA (XHM560) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM560 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5852 Anti-VEGFA (XHM561) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM561 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1242 VEGFA (FLT1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1243 VEGFA (KDR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1244 VEGFA (NRP1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1245 VEGFA (NRP2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2642 VEGFA (FLT1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2643 VEGFA (KDR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2644 VEGFA (NRP1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2645 VEGFA (NRP2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human VEGFA-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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