VivoCAR™ Anti-FCRL1 (2G5) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX45)

Name: VivoCAR™ Anti-FCRL1 (2G5) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX45
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-FCRL1 (2G5) h(CD28-41BB-CD3z) CAR circRNA features the 2G5 clone, optimized for its superior specificity and low off-target profile in the context of in-situ cell engineering. The importance of the 2G5 clone lies in its ability to identify FCRL1 epitopes that are typically inaccessible to traditional antibodies. Combined with the high translation efficiency of our circRNA platform, this product provides a potent therapeutic pulse that empowers endogenous T cells to recognize and destroy FCRL1-positive malignant cells, offering a sophisticated and safe non-viral strategy for precision hematology research.

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Target Information

Target
FCRL1

Common Name
FCRL1

Alternative Names
FCRH1, IFGP1, IRTA5, CD307a

Full Name
Fc Receptor-Like 1

Introduction
FCRL1 is a member of the Fc receptor-like family, expressed predominantly on B cells and often overexpressed in various B cell malignancies. It contains immunoreceptor tyrosine-based inhibition motifs (ITIMs), suggesting a role in regulating B cell activation. Its high expression in lymphoma and myeloma makes it an attractive and specific target for CAR-T cell therapy.

Targeting Diseases
B-cell Lymphoma, Multiple Myeloma (MM), Chronic Lymphocytic Leukemia (CLL)

UniProt ID
Q96LA6

Gene ID
115350

CAR Information

Target Species
Human

Antibody Clone
2G5

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

CAR circRNA Properties

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

circRNA Properties and Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Case Studies

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.