All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
VivoCAR™ Anti-CA9 (M75) h(CD28-41BB-CD3z) CAR circRNA features the M75 clone, recognized for its high-affinity binding to the proteoglycan-like domain of CA9. For in vivo applications, this clone is essential for its ability to distinguish malignant cells within hypoxic tumor zones. The circRNA architecture protects the transcript from degradation, facilitating sustained CAR expression on endogenous T cells. This allows for a robust, localized attack on the pH-regulating machinery of solid tumors, effectively neutralizing a key survival mechanism of aggressive carcinomas in a non-integrating format.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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