VivoCAR™ Anti-CD38 (MOR03079) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX65)

Name: VivoCAR™ Anti-CD38 (MOR03079) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX65
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD38 (MOR03079) h(CD28-41BB-CD3z) CAR circRNA features a specialized binder optimized for its unique dissociation constant, which is tailored to minimize "antigen sink" effects in the peripheral blood. For in vivo applications, the MOR03079 clone is vital for ensuring that circRNA-LNP complexes prioritize the engineering of T cells that can effectively home to the bone marrow. This non-viral approach utilizes the high translation efficiency of circular RNA to provide a safe, iterative method for purging CD38-positive plasma cell dyscrasias while protecting natural killer cell populations through its transient nature.

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Target Information

Target
CD38

Common Name
CD38

Alternative Names
ADPRC1, cADPR1, ADPRC 1

Full Name
Cluster of Differentiation 38

Introduction
CD38 is a multifunctional ectoenzyme highly expressed on Multiple Myeloma (MM) cells and other hematologic malignancies, as well as on normal B and T cells. Its widespread and high expression in MM has made it a successful target for therapeutic antibodies (like Daratumumab). CAR-T cells targeting CD38 are designed for potent anti-myeloma activity, although they must contend with CD38 expression on normal immune cells.

Targeting Diseases
Multiple Myeloma (MM), B-cell Lymphoma, Acute Myeloid Leukemia (AML)

UniProt ID
P28907

Gene ID
952

Target Species
Human

Antibody Clone
MOR03079

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD38 (MOR03079) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX65)

Target Information

Customer Reviews and Q&As

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