VivoCAR™ Anti-CD7 (CD7-FHVH10) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX74)

Name: VivoCAR™ Anti-CD7 (CD7-FHVH10) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX74
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD7 (CD7-FHVH10) h(CD28-41BB-CD3z) CAR circRNA utilizes the FHVH10 clone-a heavy-chain-only variable region-to minimize structural complexity and maximize expression efficiency. In the context of in vivo CAR-T, this single-domain binder is pivotal for its resistance to aggregation and its ability to penetrate dense T-cell lymphoma niches. By delivering this CAR as a circRNA, we enable a transient therapeutic window to eliminate CD7+ malignancies. This approach is specifically designed to address the challenge of fratricide, providing a controllable and non-permanent solution for T-cell lineage malignancies.

Add to Cart

Target Information

Target
CD7

Common Name
CD7

Alternative Names
GP40, LEU-9, TP41, Tp40

Full Name
Cluster of Differentiation 7

Introduction
CD7 is a transmembrane glycoprotein widely and consistently expressed on normal T cells and a majority of T-cell Acute Lymphoblastic Leukemia (T-ALL) cells. Its pan-T cell expression makes it an excellent target for eliminating malignant T cells. CAR development for CD7 often focuses on engineering to avoid CAR-T cell fratricide (self-killing) and managing T cell aplasia.

Targeting Diseases
T-Cell Acute Lymphoblastic Leukemia (T-ALL), T-cell Lymphoma

UniProt ID
P09564

Gene ID
924

Target Species
Human

Antibody Clone
CD7-FHVH10

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-CD7 (CD7-FHVH10) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX74). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD7 (CD7-FHVH10) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX74)

Target Information

Customer Reviews and Q&As

Related Products

CAR Cell Products

CAR Vector Products

CAR mRNA

CAR Viral Particles