VivoCAR™ Anti-CD83 (020B08) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX83)

Name: VivoCAR™ Anti-CD83 (020B08) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX83
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD83 (020B08) h(CD28-41BB-CD3z) CAR circRNA features a high-affinity clone designed to recognize CD83 overexpressed on AML blasts and certain solid tumors. The importance of the 020B08 clone for in-situ cell engineering lies in its ability to selectively target malignant cells while sparing unstimulated precursors. Combined with the circRNA platform's superior stability, this product enables a concentrated therapeutic window for treating refractory leukemia, allowing for precise, iterative dosing that maintains effector pressure on the malignancy until the transient RNA payload is naturally metabolized.

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Target Information

Target
CD83

Common Name
CD83

Alternative Names
BL11, HB15

Full Name
Cluster of Differentiation 83

Introduction
CD83 is a surface glycoprotein primarily expressed on the surface of mature Dendritic Cells (DCs), activated B cells, and a subset of activated T cells. While it plays a role in immune regulation, it is overexpressed in several hematological malignancies, including CLL and some T-cell lymphomas. Targeting CD83 aims to eliminate these malignant cells, but also offers a strategy to modulate the immune response by targeting activated DCs.

Targeting Diseases
Chronic Lymphocytic Leukemia (CLL), Hairy Cell Leukemia (HCL), T-cell Lymphoma, Multiple Myeloma (MM)

UniProt ID
Q01151

Gene ID
9308

Target Species
Human

Antibody Clone
020B08

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD83 (020B08) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX83)

Target Information

Customer Reviews and Q&As

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