VivoCAR™ Anti-GPC1 (AM4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX119)

Name: VivoCAR™ Anti-GPC1 (AM4) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX119
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-GPC1 (AM4) h(CD28-41BB-CD3z) CAR circRNA incorporates the AM4 clone to target the heparan sulfate proteoglycan GPC1, a critical co-receptor for growth factors in pancreatic ductal adenocarcinoma. By delivering this CAR via the circRNA platform, we enable a transient therapeutic window that disrupts the oncogenic signaling pathways supported by the tumor stroma. This non-integrating approach allows for the safe targeting of GPC1-expressing cancer cells while ensuring that the host's normal tissue remodeling functions are not permanently impaired by long-term CAR-T persistence.

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Target Information

Target
GPC1

Common Name
GPC1

Alternative Names
Glypican proteoglycan 1

Full Name
Glypican-1

Introduction
GPC1 is a cell surface heparan sulfate proteoglycan attached to the membrane via a glycosylphosphatidylinositol (GPI) anchor. It plays a significant role in cell signaling and growth factor regulation. GPC1 is highly overexpressed in several aggressive solid tumors, most notably Pancreatic Adenocarcinoma, where it is often detectable on tumor-derived exosomes. Its restricted expression in normal adult tissues makes it an excellent candidate for CAR-T cell therapy in "hard-to-treat" solid cancers.

Targeting Diseases
Pancreatic Cancer, Glioblastoma, Breast Cancer, Esophageal Squamous Cell Carcinoma

UniProt ID
P35052

Gene ID
2817

Target Species
Human

Antibody Clone
AM4

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-GPC1 (AM4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX119)

Target Information

Customer Reviews and Q&As

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