VivoCAR™ Anti-MUC16 (18C6) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU56)

Name: VivoCAR™ Anti-MUC16 (18C6) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU56
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-MUC16 (18C6) h(CD28-41BB-CD3z) CAR saRNA employs a high-efficiency saRNA system to deliver the 18C6 clone. For in vivo therapy, 18C6 is distinguished by its ability to navigate the complex extracellular matrix of peritoneal tumors. By utilizing the saRNA platform's biological magnification effect, the product achieves robust CAR expression following a single low-dose administration, ensuring that in situ reprogrammed T cells can sustain a long-term immune response against metastatic MUC16-positive cell clusters.

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CAR Information

Target
MUC16

Target Species
Human

Antibody Clone
18C6

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Mucin 16, Cell Surface Associated

Alternative Names
Mucin16; Ovarian Cancer Antigen CA-125; CA125

Introduction
MUC16 is the largest membrane-bound mucin and is the precursor to the CA125 biomarker. It is overexpressed in ovarian and other gynecological malignancies, contributing to peritoneal metastasis and immune evasion.

Targeting Diseases
Ovarian Cancer, Pancreatic Cancer, Endometrial Cancer, Non-Small Cell Lung Cancer (NSCLC)

UniProt ID
Q8WXI7

Gene ID
94025

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.