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Anti-U2AF2 T cell receptor (2A), pCDTCR1 (TCR-ZP053)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-U2AF2 T cell receptor (TCR) is constructed for the engineering of T cell to target Human U2AF2. The T cells are genetically modified through transduction with a lentiviral vector expressing U2AF2-specific T cell receptor. And the vector product was designed for the treatment of Colorectal cancer.

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Details

  • Target
  • U2AF2
  • Target Species
  • Human
  • Epitope
  • MMDFFNAQM
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*0201
  • Targeting Diseases
  • Colorectal cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 2A
  • Host Species
  • Yeast

Target

  • Official Symbol
  • U2AF2
  • Introduction
  • U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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