ActivatorPep™ SARS-CoV-2 Prot_S1-S (CA-LX121)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Product Name
ActivatorPep™ SARS-CoV-2 Prot_S1-S

Cat. No.
CA-LX121

Product Summary
Creative Biolabs provides an extensive cell activation reagents including Expansion Kits and Activator peptides for global custom, which are suitable to many applications, such as in vitro stimulation antigen-specific cells. SARS-CoV-2 Prot_S1 is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the N-terminal S1 domain of the surface glycoprotein ("S") of SARS-Coronavirus 2 (GenBank MN908947.3, Protein QHD43416.1). The SARS-CoV-2 Prot_S1 contains the aa sequence 1-692 of the surface glycoprotein, also termed "spike" protein. Which can be used for in vitro stimulation of SARS-CoV-2-specific T cells.

Background Information
The surface glycoprotein of SARS CoV-2, the "spike protein" is responsible for the recognition and binding of the coronavirus to the host cell. Once SARS-CoV-2 has bound to the ACE2 receptor of the host cell, fusion of viral envelope and host cell membrane starts, which enables the viral genome to enter the host cell. The spike protein consists of two functional domains: The S1 domain contains the surface binding site to the ACE2 receptor and the S2 subunit mediates membrane fusion. Cleavage at the S1/S2 boundary (aa-residues 685 and 686) via cellular proteases is crucial to prime the protein for the entry to the host cell.

Applications
Stimulation Reagents

Cross-reactivity
No significant cross-reactivity was observed among analytes in this panel.

Species Reactivity
Human

Purity or Quality Grade
Research Grade

Downstream Application
Pulsing of antigen-presenting cells for research;
Detection and analysis of antigen-specific CD4+ and CD8+ effector/memory T cells in PBMCs;

Product Size
for stimulation of 1×108 cells

Shipping Condition
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Conditions
Store at -20°C.

Shelf life
> 6 Months from date of receipt under proper storage condition.

Product Use Statement
For research use only, not for diagnostic or therapeutic use.

Product Features
Efficient expansion and increased survival rate of Ag-specific T cells;
Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells;

Principle of the Assay
In vitro stimulation of antigen-specific T cells with Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.

Research Category
Immunology

Panel Type
Stimulation for CD4+ and CD8+ T cells

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

ActivatorPep™ SARS-CoV-2 Prot_S1-S (CA-LX121)

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