anti-ACAN (aa89-103) TCR, pCDTCR1 (TCR-L007Z)

The vector of anti-ACAN T cell receptor (TCR) is constructed for the engineering of T cell to target Human ACAN. The T cells are genetically modified through transduction with a retroviral vector expressing ACAN-specific T cell receptor. And the vector product was designed for the treatment of arthritis.

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  • Target
  • ACAN
  • Target Species
  • Human
  • Epitope
  • Format
  • Non-modified
  • HLA
  • HLA–DR4+/DQ8
  • Targeting Diseases
  • Arthritis
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • TCR Host Animal
  • Human


  • Official Symbol
  • ACAN
  • Introduction
  • This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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