Closed

Anti-AURKA (YLILEYAPL) TCR, pSFG (TCR-L004)

The vector of anti-AURKA T cell receptor (TCR) is constructed for the engineering of T cell to target Human AURKA. The T cells are genetically modified through transduction with a retroviral vector expressing AURKA-specific T cell receptor. And the vector product was designed for the treatment of leukemia.

Details

  • Target
  • AURKA
  • Target Species
  • Human
  • Epitope
  • YLILEYAPL
  • Format
  • Non-modified TCR
  • HLA
  • HLA-A*0201
  • Targeting Diseases
  • Leukemia
  • Vector Name
  • pSFG
  • Vector Length
  • 8200bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Human

Target

  • Gene Name
  • aurora kinase A
  • Official Symbol
  • AURKA
  • Synonyms
  • AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Leukemia
  • Introduction
  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry
Products

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:

Online Inquiry

For any technical issues or products/services related questions, please leave your contacts as below, and our team will contact you at earliest convenience to let you know how we can be involved in your projects.

  • Verification code

Key Updates

Receive the latest news and insights to your inbox.