Anti-CCR2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0165-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-CCR2 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
CCR2

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
729230

UniProt ID
P41597

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0165-CQ	CBXC-2867	Mouse		IgG2b, λ	A synthetic peptide made to an N-terminal portion of the human CD63 protein (between residues 1-100) [UniProt P41597]
DMAb-0166-CQ	CBXC-2710	Mouse		IgG1	Human CCR2
DMAb-0167-CQ	CBXC-1209	Rat	Mouse	IgG2b	L1.2 mouse pro-B cell line transfected with mouse CCR2
DMAb-0168-CQ	CBXC-1213	Mouse		IgG2b
DMAb-0169-CQ	CBXC-0779	Human		IgG1
DMAb-0170-CQ	CBXC-1764	Mouse		IgG
DMAb-2699-FY	CBFYC-0006	Mouse	Human	IgG1	Synthetic peptide corresponding to the center region of the Human CCR2
DMAb-2700-FY	CBFYC-1070	Rat	Mouse	IgG2b	L1.2 cells transfected with mouse CCR2
DMAb-2701-FY	CBFYC-1071	Mouse	Human	IgG2	Human CCR2 transfected 293 cells
DMAb-0136-WJ	CBWJC-0985	Rabbit	Human	IgG
DMAb-0137-WJ	CBWJC-0986	Mouse	Human	IgG2a, κ	CCR2 DNA immunogen

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-CCR2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0165-CQ)

Specifications

Target

Customer Reviews and Q&As

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