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anti-CD1D TCR, pCDTCR1 (TCR-L008Z)

The vector of anti-CD1D T cell receptor (TCR) is constructed for the engineering of T cell to target Human CD1D. The T cells are genetically modified through transduction with a retroviral vector expressing CD1D-specific T cell receptor. And the vector product was designed for the treatment of cancer and autoimmune diseases.

Details

  • Target
  • CD1D
  • Target Species
  • Human
  • Format
  • Cysteine-modified
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Cancer and autoimmune diseases
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Gene Name
  • CD1d molecule
  • Official Symbol
  • CD1D
  • Synonyms
  • R3; CD1A; R3G1; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Cancer; autoimmune diseases
  • Introduction
  • This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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