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Anti-DDX5 T cell receptor (UD4), pCDTCR1 (TCR-YC0316)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-DDX5 T cell receptor (TCR) is constructed for the engineering of T cell to target DEAD-box helicase 5 (YLLPAIVHI) restricted by HLA-A*02:01. The T cells are genetically modified through transduction with a lentiviral vector expressing DDX5-specific T cell receptor.

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Details

  • Target
  • DDX5
  • Target Species
  • Human
  • Epitope
  • YLLPAIVHI
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • UD4
  • Host Species
  • Human

Target

  • Introduction
  • This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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