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Anti-G6PC2 T cell receptor, pCDTCR1 (TCR-ZP601)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-G6PC2 T cell receptor (TCR) is constructed for the engineering of T cell to target Human. The T cells are genetically modified through transduction with a lentiviral vector expressing G6PC2-specific T cell receptor. And the vector product was designed for the treatment of Others.

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Details

  • Target
  • G6PC2
  • Target Species
  • Human
  • Epitope
  • FLWSVFMLI
  • Format
  • Non-modified
  • Allele
  • HLA-A*0201
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Others
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • TE4
  • Host Species
  • Human

Target

  • Introduction
  • This gene encodes an enzyme belonging to the glucose 6 phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose 6 phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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