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Anti-Peptide APS T cell receptor (Bel502), pCDTCR1 (TCR-YC0883)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The Bel502 bound to HLA-DQ8-glia-α1 and HLA-DQ8.5-glia-α1 with a KD of 2.8 ± 0.1 μM and 19.5 ± 0.7 μM, respectively, but had no measurable affinity for DQ8/8.5-glia-γ1.

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Details

  • Target
  • Peptide APS
  • Epitope
  • APSGEGSFQPSQENPQ
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DQA1*03:01/DQB1*03:02
  • Targeting Diseases
  • Celiac disease
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Bel502
  • Host Species
  • Human

Target

  • Introduction
  • Celiac disease (CD) is a chronic inflammatory disease of the small intestine that affects ∼1.5% of whites. A small number of gliadin and glutenin peptides derived from gluten elicit this inflammatory CD4+ T cell response. CD is predominantly limited to genetically predisposed individuals, namely those who express HLA-DQ2 (DQA1∗0501-DQB1∗0201) and/or HLA-DQ8 (DQA1∗0301-DQB1∗0302). A third haplotype associated with CD is found in patients who are HLA-DQ2+ and HLA-DQ8+. These individuals can produce the trans dimer, HLA-DQ8.5 (DQA1∗0501-DQB1∗0302), which is formed by the HLA-DQ2.5 α chain and the HLA-DQ8 β chain, and has a unique peptide-binding repertoire.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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