Anti-GAD2 [286–300] TCR, pMSGV1(TCR-L022)

The vector of anti-GAD65 T cell receptor (TCR) is constructed for the engineering of T cell to target Human GAD65. The T cells are genetically modified through transduction with a retroviral vector expressing GAD65-specific T cell receptor. And the vector product was designed for the treatment of diabetes mellitus.


Details


Target
GAD65
Target Species
Human
Epitope
GAD65[286–300]
Format
Non-modified TCR
Targeting Diseases
Diabetes mellitus
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
glutamate decarboxylase 2
Official Symbol
GAD2
Gene ID
UniProt ID
Synonyms
GAD65; GAD2; glutamate decarboxylase 2; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Diabetes mellitus
Introduction
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Fax: 1-631-207-8356
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