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Anti-GAP50 T cell receptor (NB1 V58A), pCDTCR1 (TCR-YC0421)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-GAP50 T cell receptor (TCR) is constructed for the engineering of T cell to target GAP50 (GAP50 40-48) restricted by H2-Dᵇ. The T cells are genetically modified through transduction with a lentiviral vector expressing GAP50-specific T cell receptor.

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Details

  • Target
  • GAP50
  • Target Species
  • Plasmodium berghei
  • Epitope
  • GAP50 40-48
  • Format
  • Modified TCR
  • Allele
  • H2-Dᵇ
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • NB1 V58A
  • Host Species
  • Mouse

Target

  • Introduction
  • Virus-specific T cell populations have been implicated in allo-recognition. The subdominant T cell receptor JL12 recognizes both HLA-B*0801 presenting the Epstein-Barr virus-derived peptide FLRGRAYGL and also HLA-B*3501 presenting the cytochrome p450 self peptide KPIVVLHGY. This cross-reactivity could promote the rejection of HLA-B*3501-positive cells in Epstein-Barr virus-exposed HLA-B*0801 recipients. LC13, the dominant TCR against the HLA-B*0801:FLRGRAYGL complex, fails to recognize HLA-B*3501:KPIVVLHGY.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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