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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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The vector of anti-HER2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HER2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-HER2 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Breast carcinomas.
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CAR Construction : Trastuzumab-CD28-CD3ζ
Fig.4 Cytotoxicity assay XTT-based cytotoxicity assay using HER2 CAR T cells or non-modified mouse T cells and HER2 positive JIMT-1 cells as target at various (2.5:1-0.04:1) T cell to tumor cell ratios. Tóth, Gábor, et al. "A small number of HER2 redirected CAR T cells significantly improves immune response of adoptively transferred mouse lymphocytes against human breast cancer xenografts." International Journal of Molecular Sciences 21.3 (2020): 1039. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : Trastuzumab-CD28-CD3ζ
Fig.5 Antitumor activity of HER2-CAR mouse T cells in a xenograft model Quantitative measurement of tumor volumes and Kaplan-Meier survival curve. Tóth, Gábor, et al. "A small number of HER2 redirected CAR T cells significantly improves immune response of adoptively transferred mouse lymphocytes against human breast cancer xenografts." International Journal of Molecular Sciences 21.3 (2020): 1039. Distributed under Open Access license CC BY 4.0, without modification. |
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Fig.10 SPR binding assay. SPR binding sensorgrams for the interaction of HER2 wild type immobilized DARP in trastuzumab. Epa, V. Chandana, et al. "Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2." PLoS One 8.3 (2013): e59163. Distributed under Open Access license CC BY 4.0, without modification. |
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