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Anti-IL17RA T cell receptor (IF8), pCDTCR1 (TCR-YC0552)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-IL17RA T cell receptor (TCR) is constructed for the engineering of T cell to target Interleukin 17 Receptor A variant FIT_TM (FIMGISILL) restricted by HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing IL17RA-specific T cell receptor.

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Details

  • Target
  • IL17RA
  • Epitope
  • FIMGISILL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A2
  • Targeting Diseases
  • Rheumatoid arthritis
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • IF8
  • Host Species
  • Human

Target

  • Introduction
  • Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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