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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
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EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
GSE.6H9 and GSE.20D11 are the first insulin B:9–23–reactive CD4 T cells identified from inflamed pancreatic islets of patients with type 1 diabetes. GSE.20D11, was identified from a different organ donor (donor 6342) and responded to B:9–23 presented by DQ8. The levels of response to B:9–23 were dose dependent but were not as robust as that by a T-cell transductant reacting with a neoantigen or deamidated α-gliadin, and were several orders of magnitude stronger than the GSE.8E3 response to C:19–35. The minimum requirement for both GSE.6H9 and GSE.20D11 was insulin B-chain amino acids 12–22.
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