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EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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The vector of anti-SLAMF7 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human SLAMF7. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-SLAMF7 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Lung malignancy.
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CAR Construction : luc90-CD28-41BB-CD3ζ
Fig.5 In vitro cytotoxicity of luc90-CAR-T cells. Luc90-CAR-T and CD19-CAR-T effectors were incubated with 51chromium labeled MM.1S-CG or MM.1S-ΔCS1 target cells for 4 h. Chromium release was used to assess killing. O’Neal, Julie, et al. "CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+ CS1 expressing CAR-T cells." Leukemia 36.6 (2022): 1625-1634. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : luc90-CD28-41BB-CD3ζ
Fig.6 Anti-tumor Activity of luc90-CAR-T cells. Anti-tumor efficacy of Luc90-CAR-T was evaluated in NGS mice injected with MM.1S-CG cells. O’Neal, Julie, et al. "CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+ CS1 expressing CAR-T cells." Leukemia 36.6 (2022): 1625-1634. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : luc90-CD28-41BB-CD3ζ, luc90-41BB-CD3ζ
Fig.7 Anti-tumor Activity of CAR-T cells. Anti-tumor efficacy of the third generation Luc90-CAR-T, Luc90-BBz-CAR-T were compared with MND-Luc90-BBz CAR-T (lower CAR copy number) in MM.1S-CG mouse model. O’Neal, Julie, et al. "CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+ CS1 expressing CAR-T cells." Leukemia 36.6 (2022): 1625-1634. Distributed under Open Access license CC BY 4.0, without modification. |
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