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anti-Tax TCR, pCDTCR1 (TCR-L109Z)

The vector of anti-Tax T cell receptor (TCR) is constructed for the engineering of T cell to target HTLV-1 Tax. The T cells are genetically modified through transduction with a retroviral vector expressing Tax-specific T cell receptor. And the vector product was designed for the treatment of Adult T cell leukaemia (ATL).

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Details

  • Target
  • Tax
  • Target Species
  • HTLV-1
  • Format
  • Cysteine-modified
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Adult T cell leukaemia (ATL)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • TCR Host Animal
  • Mouse

Target

  • Official Symbol
  • tax
  • Introduction
  • The Tax protein of HTLV1 is an autoregulator of enhanced viral RNA transcription and it trans activates the viral 21 bp enhancer.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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