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Anti-TRPV4 T cell receptor (JG11), pCDTCR1 (TCR-YC1214)

The vector of anti-TRPV4 T cell receptor (TCR) is constructed for the engineering of T cell to target Transient receptor potential cation channel subfamily V member 3 variant FMI_A6T (FMIGYTSAL) restricted by HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing TRPV4-specific T cell receptor.

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Details

  • Target
  • TRPV4
  • Epitope
  • FMIGYTSAL
  • Format
  • Non-Modified TCR
  • HLA
  • HLA-A2
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • JG11
  • TCR Host Animal
  • Human

Target

  • Introduction
  • This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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