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Anti-VP6 T cell receptor (Rota VP6), pCDTCR1 (TCR-YC1360)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-VP6 T cell receptor (TCR) is constructed for the engineering of T cell to target Intermediate capsid protein VP6 (TLLANVTAV) restricted by HLA-A*02:01. The T cells are genetically modified through transduction with a lentiviral vector expressing VP6-specific T cell receptor.

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Details

  • Target
  • VP6
  • Target Species
  • Human rotavirus A
  • Epitope
  • TLLANVTAV
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Rota VP6
  • Host Species
  • Human

Target

  • Introduction
  • Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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