APC-labeled Human CD22 CAR Detection Reagent, His Tag (XS-0923-LX3)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Specifications

Target
CD22

Organism
Human

Application
Used for evaluating CAR expression.

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Shelf-Life
Stable as supplied until expiry date on label.

Application Notes
This product is recommended for FC application, and the optimal working dilutions should be determined by the end user.

Diseases
Leukemia, B-Cell lymphoma

Molecular Characterization
It contains AA Asp 20 - Arg 687 (Accession # P20273-1). It is the FITC labeled form of Human Siglec-2, His Tag.

Conjugation
APC

Size
25 tests; 100 tests

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Target

Target Introduction
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Target Alternative Names
CD22 Molecule

Entrez Gene ID
931

UniProt ID
P20273-1

Related Resources

Overview of CD22-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

APC-labeled Human CD22 CAR Detection Reagent, His Tag (XS-0923-LX3)

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Specifications

Target

Related Resources

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