Artificial CD4+ T Cell Stimulator (HLA-DR Restricted, K562 Cell) (XS-0425-WR11)

Name: Artificial CD4+ T Cell Stimulator (HLA-DR Restricted, K562 Cell)
SKU: XS-0425-WR11
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is a K562 cell-based artificial T cell stimulator, transduced with Invariant chain (Ii), HLA-DRA, HLA-DRB, HLA-DM, CD80, CD83, and CD64 through the retroviral expression system. It can effectively activate and stimulate human CD4+ T cells.

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Application
Human CD4+ T cells stimulation.

Matric (Cells/Biomaterials)
K562 cell

HLA Restriction
HLA-DR

Diameter
Cell-level

Form
Cellular Artificial T Cell Stimulator

Target Cell
CD4+ T cells

Target Species
Human

Surface Moieties
HLA-DRA, HLA-DRB, HLA-DM, CD80, CD83, CD64, Invariant chain (Ii)

Transduction Method
Retroviral

Co-stimulating Signal
CD80, CD83

Antigen
Peptide mix (pp65 peptide mix, 57 20-mer pp65 peptides overlapping by 10 amino acids, tetanus toxin TT830 peptide (830QYIKANSKFIGITELKK846), influenza virus HA306 peptide (306PKYVKQNTLKLAT318) and control pan-DR PADRE peptide (AKFVAAWTLKAA))

Antigen Loading
Through endocytosis or Fcγ receptor-mediated endocytosis

Antigen Presentation Pathway
MHC-dependent presentation pathway

Culture Medium/Storage solution
RPMI 1640 supplemented with 10% FCS and gentamycin.

Format
1 EA

Shipping
Dry ice

Handling advice
Avoid repeated freeze-thaw

Storage
Liquid nitrogen

Highlights
Efficient T-cell Activation; Controlled Activation; Off-the-Shelf Availability

Mycoplasma
Negative

Quality Control
This product has been tested for transduced molecule expression and effective CD4+ T cells activation.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Artificial CD4+ T Cell Stimulator (HLA-DR Restricted, K562 Cell) (XS-0425-WR11)

Customer Reviews and Q&As

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