Biotinylated Human Siglec-15 CAR Detection Reagent, His,Avitag™ (CARD-LX155)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Biotinylated Human Siglec-15 CAR Detection Reagent, His,Avitag™ is a special detection reagent which is used to detect Human Siglec-15 CAR related to the study of osteoporosis, cancer, and infectious diseases.

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Specifications

Target
Siglec-15

Application
FC, ELISA

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
osteoporosis, cancer, and infectious diseases

Molecular Characterization
It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1).

Conjugation
Biotinylated

Size
200ug

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Images
Figure 1 Structure

Target

Target Introduction
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Target Alternative Names
Siglec-15

UniProt ID
Q6ZMC9-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Biotinylated Human Siglec-15 CAR Detection Reagent, His,Avitag™ (CARD-LX155)

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Specifications

Target

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