Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Overview
As the most common type of bone cancer in male adolescents and young adults between the ages of 10 and 25, osteosarcoma originates most often from the wide ends of long bones, such as the femur, tibia in the leg, and the humerus in the upper arm. The tumor is highly malignant and can spread rapidly to other bones or/and to the lungs. Despite surgery and combination chemotherapy improvements in outcome during the last 30 years for patients with local disease, the 5-year survival rate of the sufferers with this metastatic disease remains low. CAR-T cells therapy is an attractive approach to overcome the limitation caused by the low HER2 expression level of this disease, as the engagement of a limited number of modified T-cell receptor molecules would be sufficient to trigger a cytotoxic anti-tumor effect response.
Signs, symptoms and treatments
Symptoms of osteosarcoma may be present at the tumor site, such as sharp or dull pain, welling, limping, decreased joint motion. However, the symptoms are common to other health problems, which make the diagnosis of osteosarcoma to be challenging. So it always takes weeks to months to get the diagnosis after the symptoms appearing.
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NEWSLETTER
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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