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Anti-CD19 (FMC-63) h(2B4) CAR, pCDCAR1 (CAR-MZ095)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-CD19 chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human CD19. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD19 antibody linked to 2B4 signaling domains. And the vector product was designed for the treatment of Leukemia and Neuroblastoma.

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Details

  • Target
  • CD19
  • Targeting Cell Type
  • NK cell
  • Targeting Diseases
  • Leukemia and Neuroblastoma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-2B4
  • Discription of Signaling Cassetes
  • 2B4
    CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.

Target

  • Clone
  • FMC-63
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • CD19
  • Synonyms
  • CD19;CD19; CD19 Molecule; CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4;

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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